Clinical trials are showing some promise for needle-free wrinkle removal…

ANTI-WRINKLE GEL

Doctors are achieving some successes in testing a Botox-like gel that’s aimed at smoothing away wrinkles much as Botox injections do.

Early word from doctors who are testing the gel is that it has an effect on crow’s feet wrinkles, but is not as effective as Botox, which is made by Irvine-based Allergan.

Photos of two patients treated with the gel show some improvement, but not always a dramatic change. Doctors who measured the gel’s effect said a statistically significant number of patients experienced somewhat less intense wrinkles around their eyes — for example, a change from severe to moderate crow’s feet or from moderate to mild crow’s feet a month after the treatment.

The treatment, called RT001, is still in clinical trials, which means the prospect of approval by the Food and Drug Administration remains far in the future.

The latest tests have been aimed in part at determining the concentration of peptide molecules in the gel that would be most effective in transporting the active Botox-like botulinum ingredient through the skin.

The latest tests found that, at stronger concentrations of peptide, RT001 improved the appearance of about 80 percent of patients, compared to improvements for 50 percent of the patients treated with a placebo gel with no active ingredients. Revance  Therapeutics of Mountain View, Calif., which is developing RT001, reported those results in a poster presented to the American Academy of Dermatology in August.

“The results are good, but they probably won’t be as dramatic as [Botox] injections,” dermatologist Dr. Fredric Brandt of Miami told WSVN television there.

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